Ovarian rejuvenation is a relatively new concept in the field, but one that is helping fertility specialists to make great strides forward. Using newly developed techniques, women who have suffered early menopause or other conditions which limit fertility may still conceive using their own eggs. These may include women under the age of 38 who are either postmenopausal or perimenopausal for less than 5 years, or younger women who have a low reserve of eggs. The process stimulates the ovaries, allowing for the creation and release of new eggs. In this case, any child conceived would carry genetic material from the mother. This may be the preferable option for some women, rather than using donor eggs. Injections of Growth Factors, when used for many other types of medical treatments, are made from a patient’s own blood and blood cells and is called PRP (Platelet Rich Plasma) or PDGF (Platelet Derived Growth Factors) Therapy. The procedure of ovarian rejuvenation is relatively painless and may be worth an attempt before moving on to other treatments.
Endometrium is one of the main factors in implantation and pregnancy. Pregnancy rate is increased with growing endometrial thickness. In several studies, the minimum endometrium thickness for embryo transfer was reported to be 7 mm. Some FET cycles are cancelled due to thin endometrium despite routine treatment, and there is no established protocol for this condition.
Intrauterine infusion of platelet-rich plasma (PRP) is a new approach that has been suggested for the treatment of thin endometrium. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. Recently, PRP has been used in several medical conditions in ophthalmology, orthopedics, surgery and wound healing but it’s efficacy in endometrial growth has not been fully elucidated. PRP is a safe procedure, with minimal risks of transmission of infectious disease and immunological reactions since it is made from autologous blood samples.
PRP can be instilled in the uterine cavity either with IUI catheter or under hysteroscopic guidance in the sub-endometrial zone. Which procedure would be better for you shall be decided by the treating consultant.