How Preimplantation Genetic Testing (PGT) Can Help Prevent Genetic Disorders
Synopsis
Preimplantation Genetic Testing (PGT) is a powerful tool in the realm of IVF that allows for the screening of embryos for genetic disorders before implantation. By selecting healthy embryos, PGT can significantly reduce the risk of passing on genetic conditions to future generations. This blog will explain how PGT works and its role in preventing genetic disorders.
What Is Preimplantation Genetic Testing (PGT)?
PGT involves the testing of embryos created through IVF for genetic abnormalities before they are transferred to the uterus. This testing can identify chromosomal abnormalities (PGT-A), specific genetic disorders (PGT-M), and structural rearrangements (PGT-SR), allowing parents to select the healthiest embryos for transfer.
Types of PGT and Their Applications
- PGT-A (Aneuploidy): Screens for embryos with the correct number of chromosomes, reducing the risk of miscarriage and conditions like Down syndrome.
- PGT-M (Monogenic/Single-Gene Disorders): Used when one or both parents carry a specific genetic disorder, such as cystic fibrosis or Tay-Sachs disease.
- PGT-SR (Structural Rearrangements): Detects chromosomal translocations or inversions that can lead to implantation failure or miscarriage.
Who Should Consider PGT?
- Couples with Known Genetic Disorders: If either parent is a carrier of a genetic disorder, PGT-M can ensure that only unaffected embryos are selected.
- Women of Advanced Maternal Age: PGT-A can help identify embryos with the best chance of leading to a successful pregnancy, reducing the risk of chromosomal abnormalities.
- Couples with Recurrent Miscarriages: PGT-SR can identify chromosomal issues that may be causing repeated pregnancy loss.
Benefits of PGT
By selecting embryos that are free of genetic abnormalities, PGT can increase the chances of a successful pregnancy and reduce the likelihood of genetic diseases. It also provides peace of mind to parents who are concerned about passing on genetic conditions.
A Word from Hegde Fertility
Preimplantation Genetic Testing is a valuable tool for couples undergoing IVF, particularly those at risk of passing on genetic disorders. By ensuring that only healthy embryos are implanted, PGT offers a higher likelihood of a successful pregnancy and the birth of a healthy child.
