Advanced Genetic Testing in IVF: When to Consider PGT and PGD

Synopsis

As assisted reproductive technology advances, genetic testing has become a vital component of IVF, helping to ensure the health of embryos before implantation. Preimplantation Genetic Testing (PGT) and Preimplantation Genetic Diagnosis (PGD) are two key techniques that allow for the detection of genetic abnormalities. This blog will discuss when to consider PGT and PGD during IVF and the benefits of these advanced genetic testing options.

What Is Preimplantation Genetic Testing?

PGT, or Preimplantation Genetic Testing, is used to screen embryos for chromosomal abnormalities before they are transferred to the uterus. PGT can detect conditions such as aneuploidy (abnormal number of chromosomes), which can lead to implantation failure, miscarriage, or genetic disorders like Down syndrome.

What Is Preimplantation Genetic Diagnosis?

PGD, or Preimplantation Genetic Diagnosis, is a type of PGT specifically used to detect single-gene disorders. This test is particularly useful for couples who are carriers of genetic conditions, such as cystic fibrosis, sickle cell anaemia, or Tay-Sachs disease, allowing them to select embryos that do not carry the genetic mutation.

When to Consider PGT and PGD

• Advanced Maternal Age: Women over 35 are more likely to produce embryos with chromosomal abnormalities, making PGT a valuable tool to increase the chances of a healthy pregnancy.
• Recurrent Pregnancy Loss: Couples who have experienced multiple miscarriages may benefit from PGT to identify and transfer only chromosomally normal embryos.
• Known Genetic Disorders: If one or both partners are carriers of a genetic condition, PGD can help ensure that only unaffected embryos are selected for transfer.

Benefits of These Two: Genetic Testing

• Increased Success Rates: By selecting the healthiest embryos, PGT and PGD can improve the chances of a successful pregnancy and reduce the likelihood of miscarriage.
• Reduced Risk of Genetic Disorders: PGD helps prevent the transmission of specific genetic conditions, offering peace of mind to parents with known genetic risks.
• Personalized IVF Treatment: These tests allow for a more tailored approach to IVF, improving outcomes based on each couple’s unique genetic makeup.

A Word from Hegde Fertility

Advanced genetic testing, including PGT and PGD, offers significant benefits for couples undergoing IVF, particularly those with a history of genetic disorders or fertility challenges. By selecting the best embryos for transfer, these tests can increase the likelihood of a successful pregnancy and the birth of a healthy child.