IVF Protocol – When You Have Low Ovarian Reserve

IVF Protocol – When You Have Low Ovarian Reserve

In vitro fertilization (IVF) is a common assisted reproductive technology used to achieve a healthy pregnancy. In vitro fertilization is a stepwise procedure which involves the fertilization of an egg in the laboratory condition.

The available egg in your ovaries at a time is generally considered as an ovarian reserve. When there is a decline in the number of eggs produced, it is considered as a low reserve.  Low ovarian reserve generally affects chances of your pregnancy.

The common cause of low ovarian reserve is age. The egg production declines with age. In such cases, the ovary may be in a healthy condition and function properly even when the reserve is low. Generally, a woman starts with 25,000 to 50,000 eggs at puberty and as she grows older she ends with 1000 eggs at menopause.

Causes of Low Ovarian Reserve

The common causes of Low ovarian reserve include the following:

Poor quantity of Eggs

The egg quantity may decrease due to chromosomal abnormalities such as Turner syndrome and genetic anomalies such as fragile X syndrome. This disease condition may cause a gradual decrease in egg production leading to a condition called low ovarian reserve.

Ovarian Tissue Damage

Ovarian tissue damage can also result in low ovarian reserve. The disease conditions that can cause ovarian damage include:

    • Rough torsions
    • Endometriosis
    • Triggered ovarian cyst
    • Malignant tumor
    • Benign tumor
    • Surgical removal of ovaries
    • Chemotherapy
    • Radiotherapy
    • Pelvic adhesions
    • Immunologic problems
    • A high Body mass index (BMI) can also destroy your ovarian tissues and may lead to complications.


IVF Protocol

IVF protocol differs in case of low ovarian reserve condition. If you are having a low ovarian reserve, your gynecologist will prefer either of the following protocols for in vitro fertilization treatment:

Short GnRHa Flare

Gonadotrophin releasing hormone agonist is generally administered. Your doctor will initiate this therapy at the onset of menstruation. This therapy mainly helps in stimulating the release of the follicular stimulating hormone that augments the ovarian follicular growth.

Combined Clomiphene or Gonadotrophin Stimulation

This therapy is most commonly used for IVF treatment. But it is strongly advised not to use this therapy because this therapy can harm the egg or the embryo and may lead to complication.

Mid –Follicular GnRH-Antagonist Protocol

The GnRH antagonist is given after several days of administration of GnRHa-agonist. As soon as the follicles reach a maximum size of 12mm, GnRH antagonists are added. This therapy stops the pituitary gland from secreting the luteinizing hormone.

Long GnRha Pituitary down-Regulation Protocol

This therapy is usually used by the fertility centers to deal with low ovarian reserve cases.

Agonist/Antagonist Conversion Protocol

This protocol generally inhibits FSH production and generally leads to successful results.

Get yourself tested before IVF treatment for low ovarian reserve by the IVF specialist. For suitable IVF protocol and IVF treatment, you can consult the best fertility center- Hegde fertility center. For an affordable IVF cost contact the best fertility center in Hyderabad.

 IVF center in Hyderabad are known to give more successful results when compared to other cities. Hegde fertility center being the best IVF center has experienced infertility specialist. Dr. Vandana Hegde is the best infertility specialist whom you can consult for infertility treatment.

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