{"id":6233,"date":"2022-06-13T08:11:49","date_gmt":"2022-06-13T08:11:49","guid":{"rendered":"https:\/\/hegdefertility.com\/blog\/?p=6233"},"modified":"2022-06-13T08:11:49","modified_gmt":"2022-06-13T08:11:49","slug":"abortions-and-infertility-does-genetics-have-a-solution","status":"publish","type":"post","link":"https:\/\/hegdefertility.com\/blog\/abortions-and-infertility-does-genetics-have-a-solution\/","title":{"rendered":"Abortions And Infertility: Does Genetics Have a Solution?"},"content":{"rendered":"

Infertility is a condition where it becomes impossible for two people to conceive even after a year of unprotected intercourse. It affects one in every six couples worldwide. For many, having a baby is a fairly straight forward process. <\/span><\/p>\n

However, some couples face difficulty in conception. Fertility struggle is one of the major problems in our society these days. The path to infertility is complex, painful, and stressful. There are a variety of factors that affects fertility such as ovulation defects, spermatogenic failure, parental age, obesity, and infections. <\/span><\/p>\n

Apart from these reasons the major factor that affects your fertility are genes and chromosomes. We will explain how genes hit your fertility, and how you can treat infertility issues at the genetic level.<\/span><\/p>\n

An individual\u2019s genetic information is packed into strings of DNA known as chromosomes. The arrangement of genes and chromosomes in DNA depicts the genetic makeup of an individual. Any alteration in this genetic makeup results in the disturbed functioning of the genes or disturbed chromosomal pattern. <\/span><\/p>\n

Normal human cells contain 46 chromosomes or 22 chromosomes pairs. These chromosomes are labelled 1 to 22 (the autosomes) while the X and Y are sex chromosomes. Any error\/s in the early development of egg, sperm, or embryo can lead to an abnormal number of chromosomes in the developing embryo (i.e., a missing or an extra chromosome). Chromosomal alterations or abnormalities can happen in various forms. When part of a chromosome is missing; it is called chromosomal deletions; and chromosomal mutations involve changes in DNA. <\/span><\/p>\n

There are also translocations, happen when chromosomal pieces attach to the wrong chromosome. Also, there can be inversions, where the chromosome is upside-down, and then something called aneuploidy, where there are too few or too many chromosomes. An abnormal chromosome can cause infertility, implantation failure in IVF, miscarriage, or the birth of a child with chromosomal aneuploidy. Any alteration in the gene sequence can lead to single gene mutations and can cause diseases such as Cystic Fibrosis or Huntington’s Chorea etc.<\/span><\/p>\n

Infertility at the levels of genes can occur due to various factors.<\/b><\/h2>\n

Following are some of the common ones:<\/b><\/p>\n

Family History with Genetic Problems<\/b><\/h3>\n

Oftentimes, it is proven that, a person\u2019s DNA can include all the genetic information with nothing missing or duplicated. Regardless, even they face infertility or miscarriage. In this case it is significant to understand the family history<\/a> of the person to check if any of the family member has a history of delayed pregnancy, miscarriage, or early menopause. This information is very important because it may place you at risk. <\/span><\/p>\n

If anyone in the family has experienced early menopause (before age of 40 years) the risk of having an early menopause for the subject is doubled. If someone is a carrier of an irregular chromosome, his or her embryo could receive either missing or extra genetic information, which could result in a miscarriage or other reproductive concerns. It is worth noting that these abnormalities can also occur randomly in a foetus from chromosomally normal parents, but several are passed down from generations as well. For example, consider that your mother has one X chromosome that is abnormal. <\/span><\/p>\n

This means there is 50% chance that you can inherit that irregular X chromosome which may cause conditions such as fragile X syndrome, cystic fibrosis (CF) and Tay-Sachs disease etc. All of these can cause fertility issues. Reproduction is a process that is controlled by multiple genes involved in the development of gonads, production of gametes, embryonic development, and delivery of the new-born. Any genetic mutation will hamper the process and results in reduced fertility, infertility or foetal defects.<\/span><\/p>\n

Male Infertility<\/b><\/h3>\n

Among the infertile couples, 40% of infertility issues are due to male factors. The main cause of male infertility<\/a> that is now gaining importance is genetic infertility. Any change in gene or chromosomes can cause infertility as they affect the sperm production.<\/span><\/p>\n

The following are some of the most common causes:<\/b><\/p>\n