Intra-cytoplasmic sperm injection (ICSI) is one of the assisted reproductive technologies (ART) mainly used for male infertility problems. ICSI treatment differs from conventional in vitro fertilization (IVF). The process involves inserting a single sperm into a mature egg, which is then placed in a woman’s uterus after fertilization.
ICSI is recommended to people with the following conditions:
- Low sperm count
- Poor morphology (abnormal shape) or poor motility (not moving normally) of the sperm
- If IVF is not successful
- Ejaculation problems
- Frozen sperms
- Surgically retrieved sperms
ICSI procedure involves taking fertility drugs to stimulate ovaries so as to produce more eggs. Progress will be monitored through vaginal ultrasound scans and blood tests. The eggs retrieval process is same as IVF and each egg is inserted into a single sperm.
The rest process is similar to IVF treatment. If more than one embryo is transferred, the chances of giving birth to twins or triplets are more, hence your doctor will recommend transferring a single embryo. Embryologists will examine the sperm under a microscope and determine whether the ICSI process is successful.
A fine syringe is used to collect sperms from the epididymis. This process is known as percutaneous epididymal sperm aspiration’ or PESA. Sperms can be retrieved directly from the testicles through testicular sperm aspiration process. Any tiny quantities of testicular tissue from which the sperm can be extracted can be removed through testicular sperm extraction process. In the case of stored sperm, it will be removed from frozen storage and prepared for the treatment.
Finally, a single sperm is injected into each egg. If fertilization takes place, the embryos will be stored in a laboratory for up to 3 to 5 days and the quality embryos will be transferred to the womb.
Want to undergo ICSI procedure in Hegde Fertility Consult the best Infertility Specialist to know your possibilities of success. We have the highly specialized Embryologists in place who can determine your chances and provide the best fertility treatment. Get in touch with us today to know more details on ICSI treatment cost.
Sperm DNA fragmentation is an important factor in the aetiology of male infertility that has been in the limelight in the past few years. Elevated DNA sperm fragmentation is associated with infertility, low results in fertility techniques and also with recurrent pregnancy loss Oxidative stress is the main cause of DNA fragmentation, but many endogenous and exogenous causes can contribute in the process. The desire to combat the effects of high DNA fragmentation is linked with increased apoptosis of sperms. One of the earliest changes shown by apoptotic spermatozoa is an externalization of phosphatidylserine. Magnetic activated cell sorting (MACS) is novel sperm preparation technique that separates apoptotic and non-apoptotic spermatozoa based on the expression of phosphatidylserine. This has led to the incorporation of MACS as sperm preparation technique.